Tuvuzeberberine , abantu bose barashobora kuba batamenyereye gato, ariko buriwese agomba kumenya imvugo imenyerewe: Umuntu utavuga arya coptis - ntashobora kuvuga ububabare! Nibyo, ibyingenzi byingenzi muri coptis ni berberine, ni hydrochloride ya berberine.
Berberine (BBR) ni isoquinoline alkaloide - C20H19NO5 yakuwe muri chtens ya Coptis. Ihari mu bimera bya genera 10 nimiryango 4 harimo na Berberidaceae. Crystal imeze nk'urushinge rw'umuhondo irashobora kugwa muri diethyl ether, hamwe no gushonga kwa 145 ° C. Zishobora gushonga mumazi kandi ntizishonga muri benzene, diethyl ether na chloroform.
Ubushakashatsi bugezweho bwa farumasi bwemeje ko berberine ifite intege nke zo kurwanya umutima, kurwanya arththmia, kugabanya cholesterol, gukwirakwiza imitsi irwanya imitsi, kunoza insuline, anti-platel, anti-inflammatory nizindi ngaruka. Kubwibyo, irashobora kuba ingirakamaro mu ndwara zifata umutima nimiyoboro. Ibyagutse kandi byingenzi byashyizwe mubikorwa byakuruye ibitekerezo. Nk’ubushakashatsi buherutse gukorwa ku mavuriro, berberine igira ingaruka nziza mu gukumira no kuvura hypertension, hyperlipidemiya, diyabete, arththmia, ibibyimba n'izindi ndwara. Hydrochloride ya Berberine yavuzwe cyane mu kugabanya lipide yamaraso. BBR irashobora kugenga imvugo ya lipoprotein reseptor LDLR kandi igatera kwinjiza poroteyine ya LDL na selile yumwijima. BBR ihindurwamo dihydroberberine (dhBBR) na nitroreductase ya amara yo mu nda ya microbiota yo mu mara, bigatuma byinjira mu mara byoroshye. Nyuma yo kwinjizwa, iba oxyde muri BBR mumyanya yo munda ikinjira mumaraso. Kugera ku ngaruka zo kugabanya lipide na hypoglycemic. BBR irashobora kandi kunoza imbaraga za metabolism. Ubuyobozi bwo mu kanwa bwa BBR butera microbiota yo mu nda kubyara butyrate, yinjira mu maraso kandi ikora kuri SCFAs (acide fatty fatty acide), igabanya lipide yamaraso hamwe nisukari mu maraso.
BBR irashobora guteza imbere kuvugurura ingirabuzimafatizo zo mu bwoko bwa pancreatic islet kandi ifite ibyiza byinshi kuruta indi miti irwanya diyabete. Igeragezwa ry’amavuriro ryerekanye ko berberine ishobora kubuza fibrosis ya myocardial imbeba za diyabete; BBR ifite anti-platelet, irashobora kongera nucleotide muri platine kandi ikabuza kwegeranya. Berberine ifatanije na statine igira uruhare runini mu guhagarika okiside ya plasma trimethylamine mu ndwara z'umutima no guhagarika ikorwa rya aterosklerose.
Ubushinwa berberine nuburyo bwiza bwibiyobyabwenge bya "statin". Kubera ko berberine ihendutse inshuro nyinshi kuruta imiti ya “statine”, kuvumbura ingaruka za berberine zigabanya amaraso-lipide igabanya agaciro ntagereranywa mu gukumira no kuvura hyperlipidemiya, diyabete n'indwara z'umutima.
Twandikire】
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Igihe cyo kohereza: Mutarama-08-2024
