NAD Mbere-Indanga Intangiriro

NAD + ni coenzyme ikomeye, izina ryayo ryuzuye ni nicotinamide adenine dinucleotide. Ibaho cyane muri selile kandi igira uruhare mubikorwa byinshi bya biohimiki. NAD + igira uruhare runini mubikorwa byinshi byibinyabuzima, harimo imbaraga za metabolism, guhumeka selile, gusana ADN, kwanduza gene, no gusaza. Irashobora kunguka cyangwa kurekura electron muri yo binyuze muburyo butandukanye bwibinyabuzima. Muri ubu buryo, ibisubizo NAD + ishobora guhagarika harimo redox, kugabanya karubone, kwimura acyl, nibindi. Nka coenzyme, umurimo nyamukuru wa NAD + ni uguhindura electron na hydrogène ion muri enzyme-catalizike. Muri iki gikorwa, NAD + igabanywa kuri NADH, bityo igatanga electron na hydrogen ion kubindi bisabwa bya enzyme. NAD + nayo yakuruye ubumenyi bwa siyanse mumyaka yashize kuko ikekwa ko igira uruhare mugusaza. Ubushakashatsi bwerekanye ko mugihe cyo gusaza, urwego rwa NAD + mu ngirabuzimafatizo rugabanuka, kandi kuzuza NAD + bishobora guteza imbere imbaraga za selile metabolism, gusana ADN no gutinda gusaza. Byongeye kandi, NAD + yasanze kandi ifite uruhare runini mu gusana ibyangiritse kuri ADN, apoptose, gukora enzymes no kugenzura imiterere ya gene. Kugeza ubu, abantu barimo gukora ubushakashatsi bwimbitse kuri NAD + n'uruhare rwayo muri physiologiya na patologiya, kugirango bavumbure byinshi kumikorere n'imikorere ya NAD +.