Gusaza kwabantu ni amategeko karemano yisi yose. "Ibinyabuzima na selile Biologiya yo gusaza" byerekana incamake yubushakashatsi bwashaje kandi buvuga ko gusaza biterwa no kwangirika kwa okiside no kugabanuka kurwego rwa NAD +.
Birashobora kugaragara ko NAD + igira uruhare runini mubinyabuzima, kandi ifitanye isano rya hafi n'indwara zandura n'indwara.
NAD + yitwa nicotinamide adenine dinucleotide, cyangwa coenzyme I kubugufi. Ifite uruhare runini mubikorwa bitandukanye byibanze byimiterere yibinyabuzima, bityo bikagira ingaruka ku kugarura ingufu, kurwanya kwangirika kwa okiside, gusana ADN, kugenga ingirabuzimafatizo na genome bigenzura gusaza mu ngirabuzimafatizo, gucika intege cyangwa no guhagarika ingirabuzimafatizo zimwe na zimwe zishaje, bityo bikadindiza neza. iterambere ry'umurongo. Hasi, reka turebe neza:
1.Akamaro ka NAD +
Nka imwe muri metabolite yingenzi mumubiri wumuntu, NAD + yameze neza igizwe numusaruro wibinyabuzima, gukoresha, kuzenguruka no kwangirika igihe kirekire.
Guhera muri 30, urwego rwa NAD + mumubiri wumuntu ruzerekana inzira yo kumanuka uko abantu basaza. Kugabanuka kwibintu bya NAD + muri selile nabyo bizagabanya kugabanuka kwubushobozi bwo gusana ADN, kwihutisha kwegeranya kwangirika kwa ADN, hanyuma biganisha ku kurimbuka kwa NAD + Ibirimo bikomeza kugabanuka, bikagira uruziga rukabije rwo gusaza vuba kandi vuba.
Tuvuze ko NAD + igira uruhare mu gusana ADN cyane cyane ko ari substrate yumuryango wa PARP. Hamwe na NAD +, PARP irashobora kugira uruhare rwayo. Ku rundi ruhande, PARP nayo ni imwe mu "baguzi" nyamukuru ba NAD + mu tugari. NAD + yakoreshejwe na PARP ihinduka nicotinamide NAM, hanyuma igatemba munzira yo gutabara, hanyuma NAD + irongera ikomatanya hifashishijwe NAMPT, NMNAT nindi misemburo. Iyo selile zifite ibibazo (harimo na ADN yo gusana ADN), umubare munini wa NAD + uhindurwamo unyuze munzira yo gukiza kugirango ugumane uburinganire hagati yo gutanga nibisabwa.
NAD + igira uruhare mu gusana ADN nka Sirtuins substrate
Sirtuins ni umuryango wa protein deacetylase igizwe nabanyamuryango 7 (SIRT1-SIRT7). SIRT1, SIRT6, na SIRT7 bibaho muri nucleus, SIRT2 igira uruhare muri cytoplazme, naho SIRT3, SIRT4, na SIRT5 ni poroteyine za mito-iyambere. Sirtuins zimwe (cyane cyane SIRT1 na SIRT6) zigira uruhare runini mugusana ADN no guhinduranya selile nyuma yo kwangirika kwa ADN.
3.NAD + metabolism n'imikorere ya physiologique
01. Komeza redox homeostasis
Kugumana uburinganire bwa okiside yo mu nda na antioxydants ni urufunguzo rw'utugingo ngengabuzima kugira ngo dukore imirimo isanzwe ya physiologiya. Nyamara, ibitera ingaruka mbi nko guhumana, guhindura imirire no kwandura birashobora guhungabanya ubwo buringanire kandi bigatera kwangirika kwa macromolecules nka ADN na proteyine. Kuzuza NAD + birashobora kugira uruhare mu kurinda okiside mu kongera urwego n'ibikorwa bya glutathione hamwe na enzymes za antioxydeant.
02. Komeza genome itajegajega
Kubura NAD + bizatera inzitizi zo gusana ibyangiritse kuri ADN, bitera kwangirika kwinshi kwa ADN kwiyegeranya, kandi kuzuza NAD + birashobora gufasha gusana ADN.
03. Kugenzura urwego rwubudahangarwa no gutwikwa
Usibye NAD + ubwayo ibasha kugabanya umuvuduko ukabije wogutezimbere imikorere ya lysosomal, enzyme ya NAMPT ikenewe muri metabolism nayo nigice cyingenzi cyo kugenzura ubudahangarwa. Kuzuza NAD + bifasha kugenzura ubudahangarwa no gutwikwa.
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