Berberine hydrochloride

Ifite ingaruka mbi kuri Escherichia coli, Escherichia coli, Diplococcus pneumoniae, Staphylococcus aureus, Streptococcus, Typhi na amibe. Mubuvuzi, ikoreshwa cyane mugusenya indwara na bagiteri. Byagaragaye kandi ko iki gicuruzwa gifite anti-arththmic. Berberine ifite ibikorwa byo kurwanya ibibyimba muri vitro kandi irashobora gutera ururenda rwa selile B16; kimwe na cytarabinehydrochlorideifite ingaruka nziza muri vitro.

Intego
Alkaloide ya isoquinoline. Inzira ya molekulari [C20H18NO4] +. Azwi kandi nka berberine. Ibaho mubihingwa byinshi muri genera 10 nimiryango 4 harimo na Berberidaceae. Berberine irashobora kugusha inshinge zumuhondo zimeze nka kristu ziva muri diethyl ether. Gushonga ingingo 145 ℃. Gushonga mumazi, kudashonga muri benzene, ether na chloroform. Berberine ni alkaloide ya kane ya amonium, kandi gukomera kwumunyu wacyo mumazi ni bito, urugero, hydrochloride ni 1: 500 na sulfate ni 1:30. Kirisiti ya berberine yaguye mu mazi cyangwa etanol ya dilute irimo molekile 5.5 y'amazi ya kirisitu; niba ikozwe muri chloroform, acetone cyangwa benzene, irimo na molekile ihuye na kristu. Berberine irashobora kuvurwa hamwe na alkali itandukanye kugirango ibone uburyo butatu bwa berberine: uburyo bwa ammonium ya quaternary, form ya aldehyde nuburyo bwa alcool, muribwo buryo bwa amonium ya quaternary aribwo butajegajega. Berberine igira ingaruka za antibacterial kuri hemolytic Streptococcus, Staphylococcus aureus, Neisseria gonorrhoeae, Freundii na Shigella dysenteriae, kandi ikongerera fagocytose ya selile yera. Hydrochloride ya Berberine (bakunze kwita berberine hydrochloride) yakoreshejwe cyane mu kuvura gastroenteritis, dysenterie bacillary, n'ibindi, kandi ikagira n'ingaruka zimwe na zimwe ku gituntu, umuriro utukura, toniillillite ikaze n'indwara z'ubuhumekero.

farumasi
farumasi
Ifite antibacterial spécran kandi ifite ingaruka za antibacterial kuri bacteri zitandukanye za Gram-positif na -negative bagiteri muri vitro, harimo na hemolytic Streptococcus, Staphylococcus aureus, na kolera ya Vibrio. Meningococci, Shigella dysenteriae, Tifoyide bacilli, Diphtheria bacilli, nibindi bifite ingaruka zikomeye zo kubuza. Ni bacteriostatike yibitekerezo bike kandi ikabyara cyane. Ifite kandi ingaruka zimwe na zimwe zibuza virusi ya grippe, amibe, leptospira, n'uruhu runaka. Mu bushakashatsi bwa vitro bwemeje ko berberine ishobora kongera ubushobozi bwa fagocytike ya leukocytes na sisitemu reticuloendothelial. Shigella dysenteriae, hemolytic Streptococcus, Staphylococcus aureus, nibindi birwanya byoroshye iki gicuruzwa. Nta kwambukiranya hagati yiki gicuruzwa na penisiline na streptomycine.

Imiti ya farumasi
Kwinjira mu kanwa nabi. Nyuma yo guterwa, ihita yinjira mu ngingo zitandukanye no mu ngingo zitandukanye, kandi amaraso agumaho mu gihe gito. Ubwinshi bwamaraso nyuma yo guterwa inshinge ziri munsi yubushakashatsi buke. Umuti ukwirakwizwa cyane, cyane cyane mumutima, amagufwa, ibihaha numwijima. Igihe cyo kugumana mumyenda ni kigufi, kandi hasigaye gusa amasaha 24. Imiti myinshi ihindagurika kandi ikavaho mu mubiri, kandi munsi ya 5% yimiti yatanzwe isohoka muburyo bwambere mugihe cyamasaha 48.
Nk’uko amakuru aheruka kubigaragaza, bemeza ko iki gicuruzwa gishobora kugabanya umubare wa pili hejuru ya bagiteri, bikarinda bagiteri kwizirika ku ngirabuzimafatizo z’abantu, kandi bikagira ingaruka zo kuvura. Iki gicuruzwa kandi kigira ingaruka kuri Helicobacter kandi gishobora kugabanya ibisebe bya gastrite, gastric na duodenal.

Yahagaritswe kandi akoreshwa yitonze
Nubwo ishobora gukoreshwa mu bana, iranduzwa ku bana bafite glucose-6-fosifate dehydrogenase ibura kuko iki gicuruzwa gishobora gutera amaraso make kandi bigatera indwara ya jaundice.

Ingaruka mbi
.
. Mugihe gikomeye, syndrome ya Aspen irashobora kubaho, ndetse nurupfu. Ubushinwa bwatangaje ko buzakuraho inshinge zitandukanye za berberine hydrochloride.
Abantu bake bafite uburibwe bwinda bwinda cyangwa igifu, kuribwa mu nda cyangwa impiswi.

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