Ahanini imikorere ya Spermidine na Spermidine trihydrochloridecan mubushakashatsi

Ahanini imikorere yerekeyeSpermidine naSpermidine trihydrochlorideirashobora mubushakashatsi

Spermidine [N- (3-aminopropyl) -1,4-diaminobutane] ni triamine yuzuye umurongo wa triamine ikunze gushyirwa mubikorwa hagati yigihe cyo guhuza intanga. Ifite molekuline C1H19N3 hamwe na misa ya 145,25 g / mol kandi ni molekile ntoya, ibora amazi, amphifilique ifite ubushobozi bwo kwinjira mubice byibinyabuzima. Bibaho mu binyabuzima byinshi, tutitaye ku matagisi ya tagisi.

Spermidine irashobora guhuza ubwoko bwinshi bwa molekile, ikagira akamaro kanini. Bashyigikira inzira zirimo gukura kwingirabuzimafatizo, ADN itajegajega, ikwirakwizwa rya selile na apoptose. Bigaragara ko polyamine ikora muburyo busa nibintu bikura mugihe cyo kugabana. Niyo mpamvu intanga ngabo ari ingenzi mu mikurire myiza yimikorere.

1.Anti-inflammatory ya Spermidine kuri kanseri nubuzima bwumutima

Mu bushakashatsi bwakozwe mu 2016, spermidine yasanze ihindura isaha yo gusaza no kunoza imikorere yumutima nimiyoboro yimbeba zishaje. Kurwego rwumubiri, imiterere yumutima nimikorere byateye imbere mumbeba zishaje zahawe spermidine. Metabolism nayo yatejwe imbere muri izo mbeba kubera kugarura imiterere ya mitochondial n'imikorere nyuma yo kongerwamo intanga.

2. Spermidinegukora nka anti-gusaza ibiyigize

Ku bijyanye no kuramba, ubushakashatsi bwinshi bw’inyamaswa bwerekanye ko gufata spermidine byongera ubuzima kandi bikarinda fiboside yumwijima na kanseri ya hepatocellular. Bisa nkaho ari ukuri kubijyanye nimirire ikungahaye kuri polyamine. Hariho kandi ibimenyetso bimwe byerekana ko byongera imbaraga zo guhangayika, kandi kugabanuka kwimyaka bijyanye na spermidine bifasha iterambere ryindwara ziterwa nimyaka.

3.Spermidine trihydrochloriderkwigisha Kugabanuka Kumenya

Ubushakashatsi bwasohotse mu kinyamakuru Cell Reports mu 2021 burambuye ko spermidine yimirire iteza imbere kumenya no gukora imikorere ya mitochondial mu isazi nimbeba, kandi itanga amakuru yumuntu.