Ubumenyi | Ingaruka yera kwisiga ibikoresho fatizo - arbutin Igice cya gatatu

Uburyo bwo kuvoma ibimera bisanzwe

Ubu buryo bukoresha cyane cyane ibibabi byibimera byo mu bwoko bwa Ursi nkibikoresho fatizo, kandi bigakoresha ibimera biva mu buhinzi, kubikuramo, chromatografi yinkingi nubundi buryo bwo gutandukanya no kweza kugirango ubonearbutin gukuramo. Nko mu 1930, byavuzwe koarbutin ikubiye mu mababi ya cabage. Ubushakashatsi bwakurikiyeho bwemeje ko arbutine iboneka no mu bibabi byumuceri wumukara, bilberry, idubu nigiti cyitwa puwaro. glycoside.

Kubera ko ibirimo arbutine mu bimera ari bike cyane, uburyo bwo kuyikuramo buragoye, kandi ubuziranenge bwibikomokaho ntabwo buri hejuru, bityo hamwe nogutezimbere ubundi buryo bwo gutegura, uburyo bwo kuvoma ibihingwa bwagiye butakaza inyungu zayo zo guhatana.

Umuco wibimera

Uburyo bwimico yumubiri wibimera bukoresha ubushobozi bwa glycosylation yingirabuzimafatizo kugirango bihindure hydroquinone muri arbutine. Ugereranije nuburyo bwo kuvoma ibimera, imikorere yo kubona arbutine ukoresheje uburyo bwimico yumuco wibimera biri hejuru cyane. Iyo ukoresheje ubu buryo, guhitamo umuco wimiterere yimiterere yimiti no kumenya imico ikwiye nibyingenzi.

T. we ibikoresho fatizo bikoreshwa muburyo bwumuco wumuco wibimera bifite isuku, igipimo cyo guhinduka ni kinini, kandi umusaruro nta mwanda. Nyamara, umusaruro wigihe kirekire, gutandukana no kwezwa biragoye, kandi iterambere ryinganda ntirirakura. Kurushaho gusobanukirwa uburyo bwo gukura kwingirabuzimafatizo, gusobanura ibintu byingenzi bigira uruhare mubikorwa bya synthesis, kugabanya umusaruro, no kongera umusaruro nibibazo byingenzi bigomba gukemurwa mugukoresha ubu buryo.

Uburyo bwa synthesis

Uburyo bwa enzyme synthesis ikoresha cyane cyane glycosyltransferase cyangwa glycosidase nkumusemburo wo guhagarika glycosyl no guhindura hydrolysis reaction yo guhuza glycoside, ni ukuvuga ko arbutine iboneka muri hydroquinone na glucose munsi ya catalizike ya glycosidase.

Uburyo bwa enzyme synthesis ifite inzira yoroshye, gukora neza cyane, hamwe nibyiza byiterambere. Hamwe nubushakashatsi bwimbitse kuri ubu buryo mumyaka yashize, havumbuwe zymogene nyinshi kandi zikwiye, kandi igipimo cya synthesis ya arbutin nacyo kigenda cyiyongera. Byizerwa ko ubu buryo buzaba bumwe mubyerekezo byingenzi byubushakashatsi kuri synthesis ya arbutin mugihe kizaza. imwe.

Gukomatanya imiti

Mubisanzwe, synthesis ya chimique ya arbutin ikoresha glucose na hydroquinone nkibikoresho fatizo. Nyuma yuko byombi birinzwe neza, bahura na glycosidation hanyuma bakuraho itsinda ririnda. Uburyo bwa synthesis ya chimique bwabaye uburyo bwingenzi bwo gutegura arbutine kubera ibyiza byayo byiza byubukorikori bwiza hamwe nigiciro gito cy’umusaruro, kandi byageze ku musaruro w’inganda mu gihugu no hanze yacyo.

Kugeza ubu, mu Bushinwa, glucose ya anhydrous ikoreshwa nkibikoresho fatizo, kandib -arbutine ikorwa binyuze mu kurinda acylation, kanseri ya catalitike, na hydrolysis ya alkaline. Hamwe niterambere rihoraho ryikoranabuhanga rya synthesis, mumyaka yashize, intambwe zo guhuza imbere murugo rwa arbutin zagiye zoroha buhoro buhoro, igipimo cya synthesis cyarushijeho kunozwa, kandi ireme ryageze kurwego mpuzamahanga rwateye imbere. Nyamara, kubera stereoselectivitike yibicuruzwa muri synthesis ya chimique, haracyakenewe ubushakashatsi bwimbitse kugirango habeho uburyo bwiza kandi bwihariye bwo guhuza imiti yo guteguraa-arbutin.

Umutekano wa arbutin

Kubera ko hydroquinone igira ingaruka zo kubuza tyrosinase, yakoreshejwe mu kwisiga hakiri kare anti-freckle no kwisiga byera kugirango igabanye uruhu. Nyuma ubushakashatsi bwerekanye ko hydroquinone ifite ibyago byo gutera indwara ya ochronose na vitiligo, ndetse no gukangurira kanseri. Ingaruka zishobora kubaho, urutonde nkibintu bibujijwe kwisiga mu gihugu cyanjye. Arbutin kandi ni inhibitor ya tyrosinase kandi isimbuza hydroquinone. Mubihe nkibiciro bya pH bike, ubushyuhe bwinshi, hamwe na ultraviolet irrasiyo, arbutine irashobora guhinduka hydroquinone ikorwa na mikorobe y’uruhu cyangwa glucosidase, bikaviramo ingaruka ziterwa no gukangurira, genotoxicite, cyangwa kanseri. Kubwibyo, ubushakashatsi bwumutekano wa arbutin burigihe bwagiye bukurura inganda.

Muri Gashyantare 2023, SCCS yatanze igitekerezo cyanyuma ku mutekano waa-arbutin nab-arbutine mu kwisiga (SCCS / 1642/22), hamwe n'imyanzuro ikurikira

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